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A concise one-pot synthesis of [18F]fluoromisonidazole from (2R)-(−)-glycidyl tosylate

✍ Scribed by Masao Tada; Ren Iwata; Hiroshi Sugiyama; Kazunori Sato; Kazuo Kubota; Roko Kubota; Hiromu Takahashi; Hiroshi Fukuda; Tatsuo Ido

Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
207 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis

A rapid, one-pot synthesis of [isF]fluoromisonidazole (1H-l-(3-[isF]fluoro-2hydroxypropyl)-2-nitroimidazole) (1) starting from ['sF]fluoride and (2R)-(-)-glycidyl tosylate (2) is described. The total time required for the synthesis, the radiochemical yield, and purity of the titled compound are ca. 80 min, 20%, and >98%, respectively.

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