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A new synthesis of the labeling precursor for [18F]-fluoromisonidazole

✍ Scribed by Tom C. H. Adamsen; John R. Grierson; Kenneth A. Krohn

Publisher
John Wiley and Sons
Year
2005
Tongue
French
Weight
83 KB
Volume
48
Category
Article
ISSN
0022-2135

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✦ Synopsis

18

F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors.

The precursor for [ 18 F]-fluoromisonidazole was prepared from 1,3-dibromo-2propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis was 18%.

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