Several nucleoside analogues like l-(~-D-glucopyranosyl)-5-fluorouracil 10, 1-(~-D-galactopyranosy1)-5-fluorouracil 11 and l-(2-deoxy-PD-glucopyranosyl)-5-fluorouracil 12 have been synthesized. From the corresponding 1-(2',3',4',6-tetra-O-acetyl-~-D-glycop~anosyl)-uracils 4, 5 and 6, the I8F labell
The synthesis of 18F-labeled potent anesthetics
✍ Scribed by RJ Nickles; MR Satter; JR Votaw; JJ Sunderland; CC Martin
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 124 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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A one‐step ^18^F‐labelling strategy was used to prepare three labelled analogues of the vitamin biotin, which can be useful as tracers because of biotin's high affinity for avidin. The labelled compounds were obtained in decay‐corrected yields of up to 35% and specific radioactivity of 320 GBq/µmol.
## Abstract Several [^18^F]‐labeled α‐trifluoromethyl ketones have been synthesized. Reactions of 2,2‐difluoro‐1‐aryl‐1‐trimethylsiloxyethenes (**1a–d**) with [^18^F]‐F~2~ at low temperature produced [^18^F]‐labeled α‐trifluoromethyl ketones (**2a–d**). Radio‐labeled products were isolated by purif
18 F]-Fluoromisonidazole is the most widely used radiopharmaceutical for imaging hypoxia in tumors. The precursor for [ 18 F]-fluoromisonidazole was prepared from 1,3-dibromo-2propanol in 5 steps from available materials and straightforward purification steps. The overall yield for this synthesis