𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Synthesis of 18F-labelled biotin analogues

✍ Scribed by Elisabeth Blom; Oleksiy Itsenko; Bengt Långström

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
375 KB
Volume
54
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

A one‐step ^18^F‐labelling strategy was used to prepare three labelled analogues of the vitamin biotin, which can be useful as tracers because of biotin's high affinity for avidin. The labelled compounds were obtained in decay‐corrected yields of up to 35% and specific radioactivity of 320 GBq/µmol. When evaluated in situ, the analogues showed good affinity for avidin: 60–75% of the radiolabelled compounds were bound to avidin within 5 minutes. The binding was site‐specific, as shown by blocking experiments with native biotin.

📜 SIMILAR VOLUMES

Synthesis of 18F labelled nucleoside ana
Synthesis of 18F labelled nucleoside analogues
✍ Roland Haeckel; Klaus Weber; Christine Germann; Uwe Haberkorn; Stefan Zeisler; J 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 452 KB 👁 2 views

Several nucleoside analogues like l-(~-D-glucopyranosyl)-5-fluorouracil 10, 1-(~-D-galactopyranosy1)-5-fluorouracil 11 and l-(2-deoxy-PD-glucopyranosyl)-5-fluorouracil 12 have been synthesized. From the corresponding 1-(2',3',4',6-tetra-O-acetyl-~-D-glycop~anosyl)-uracils 4, 5 and 6, the I8F labell

Synthesis of [18F]-labeled adenosine ana
Synthesis of [18F]-labeled adenosine analogues as potential PET imaging agents
✍ Mian M. Alauddin; John D. Fissekis; Peter S. Conti 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 124 KB

## Abstract __The__ syntheses of adenosine analogues, 2′‐deoxy‐2′‐[^18^F]fluoro‐9‐β‐D‐arabinofuranosyladenine ([^18^F]‐FAA) and 3′‐deoxy‐3′‐[^18^F]fluoro‐9‐β‐D‐xylofuranosyladenine ([^18^F]‐FXA) are reported. Adenosine (**1**) was converted to its methoxytrityl derivatives **2** and **3** as a mixt

18F-Labelled vorozole analogues as PET t
18F-Labelled vorozole analogues as PET tracer for aromatase
✍ Maria Erlandsson; Farhad Karimi; Kayo Takahashi; Bengt Långström 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 173 KB

## Abstract One‐ and two‐step syntheses for the ^18^F‐labelling of 6‐[(__S__)‐(4‐chlorophenyl)(1__H__‐1,2,4‐triazol‐1‐yl)methyl]‐1‐(2‐[^18^F]fluoroethyl)‐1__H__‐benzotriazole, [^18^F]FVOZ, 1 and 6‐[(__S__)‐(4‐chlorophenyl)(1__H__‐1,2,4‐triazol‐1‐yl)methyl]‐1‐[2‐(2‐[^18^F]fluoroethoxy)ethyl]‐1__H__‐

Synthesis of [18F] analogues of MK-801
Synthesis of [18F] analogues of MK-801
✍ A. Denis; C. Crouzel 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 French ⚖ 73 KB

The major excitatory amino acids in mammalian CNS. L. glutamate and L. aspartate, have neurotoxic activity mediated through excitatory synaptic receptors such as N-methyl-Daspartate (N.M.D.A) receptor subtype.These excitotoxics amino acids have been implicated in several brain damages associated wit

Synthesis of 18F-labelled biphenyls via
Synthesis of 18F-labelled biphenyls via SUZUKI cross-coupling with 4-[18F]fluoroiodobenzene
✍ Björn Steiniger; Frank R. Wuest 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 147 KB

The Suzuki reaction of organoboron compounds with 4-[ 18 F]fluoroiodobenzene has been developed as a novel radiolabelling technique in 18 F chemistry. The crosscoupling reaction of p-tolylboronic acid with 4-[ 18 F]fluoroiodobenzene was used to screen different palladium complexes, bases and solvent