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Synthesis of [18F] analogues of MK-801

✍ Scribed by A. Denis; C. Crouzel

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 73 KB
Volume: 26
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.25802601149

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✦ Synopsis

The major excitatory amino acids in mammalian CNS. L. glutamate and L. aspartate, have neurotoxic activity mediated through excitatory synaptic receptors such as N-methyl-Daspartate (N.M.D.A) receptor subtype.These excitotoxics amino acids have been implicated in several brain damages associated with epilepsy. anoxia-ischemia and hypoglycemia (1).

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