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Expedient synthesis of [18F]-labeled α-trifluoromethyl ketones

✍ Scribed by G. K. Surya Prakash; Mian M. Alauddin; Jinbo Hu; Peter S. Conti; George A. Olah

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
97 KB
Volume
46
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Several [^18^F]‐labeled α‐trifluoromethyl ketones have been synthesized. Reactions of 2,2‐difluoro‐1‐aryl‐1‐trimethylsiloxyethenes (1a–d) with [^18^F]‐F~2~ at low temperature produced [^18^F]‐labeled α‐trifluoromethyl ketones (2a–d). Radio‐labeled products were isolated by purification with column chromatography in 22–28% yields, decay corrected (d.c.) in three runs per compound. Radiochemical purity was >99% with specific activities 15–20 GBq/mmol at the end of synthesis (EOS). The synthesis time was 35–40 min from the end of bombardment (EOB). This one‐step simple method is highly useful for the radiochemical synthesis of potential biologically active [^18^F]‐labeled α‐trifluoromethyl ketones for PET imaging. Copyright © 2003 John Wiley & Sons, Ltd.

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