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A General Method of Halogenation for Synthesis of α-Halodifluoromethyl Ketones and [18F]-Labeled Trifluoromethyl Ketones.

✍ Scribed by G. K. Surya Prakash; Jinbo Hu; Mian M. Alauddin; Peter S. Conti; George A. Olah


Publisher
John Wiley and Sons
Year
2003
Weight
98 KB
Volume
34
Category
Article
ISSN
0931-7597

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A Simple Method for the Preparation of Aryl Trifluoromethyl Ketones. -The pyridinium trifluoroacetate (III) is shown to be an effective, easy to handle and stable trifluoroacetylation agent for electron-rich aromatic compounds. The reaction can be carried out as a one-pot procedure.