## Abstract Dynamic nuclear polarization can be used to increase the sensitivity of solution state ^13^C magnetic resonance spectroscopy by four orders of magnitude. We show here that [1β^13^C]glutamate can be polarized to 28%, representing a 35,000βfold increase in its sensitivity to detection at
Application of hyperpolarized [1-13C]lactate for the in vivo investigation of cardiac metabolism
β Scribed by Dirk Mayer; Yi-Fen Yen; Sonal Josan; Jae Mo Park; Adolf Pfefferbaum; Ralph E. Hurd; Daniel M. Spielman
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 267 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0952-3480
- DOI
- 10.1002/nbm.2778
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We report studies of the effect of ischemia on the metabolic activity of the intact perfused lung and its restoration after a period of reperfusion. Two groups of rat lungs were studied using hyperpolarized 1β^13^C pyruvate to compare the rate of lactate labeling differing only in the temporal order
## Abstract The fate of the ^13^C label arising from [ Uβ^13^C ] succinate in rabbit renal proximal convoluted tubular (PCT) cells, incubated with [Uβ^13^C]succinate, was investigated by ^13^C NMR spectroscopy of the perchloric acid extracts of the cell pellets. The ^13^C label of [Uβ^13^C] succina