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Design of a 13c {1h} rf probe for monitoring the in vivo metabolism of [1-13c] glucose in primate brain

✍ Scribed by B. E. Hammer; W. Sacks; R. E. Bigler; M. J. Hennessy; S. Sacks; A. Fleischer; P. B Zanzonico

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
255 KB
Volume
13
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The design of an RF probe suitable for obtaining proton‐decoupled ^13^C spectra from a subhuman primate brain is described. Two orthogonal saddle coils, one tuned to the resonant frequency of ^13^C and the other to the resonant frequency of ^1^H, were used to monitor the in vivo metabolism of [1‐^13^C] glucose in rhesus monkey brain at 2.1 T. Difference spectra showed the appearance of ^13^C‐enriched glutamate and glutamine 30 to 40 min after a bolus injection of [ 1‐ ^13^C] glucose.

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