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APC and β-catenin protein expression in adenomas of patients with familial polyposis

✍ Scribed by Iwamoto, Michiko; Giardiello, Francis M.; Boland, C. Richard; Romans, Kathy; Chauhan, Dharam P.; Ahnen, Dennis J.


Book ID
124127400
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
178 KB
Volume
120
Category
Article
ISSN
0016-5085

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Familial adenomatous polyposis (FAP) represents a human model of the adenomasarcinoma sequence. Colectomy substantially reduces the cancer risk. Restorative proctocolectomy maintains continence and abolishes the risk of rectal cancer, but there is a price to pay in terms of an increased morbidity ra