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APC gene mutations in a jejunal adenoma causing intussusception in a patient with familial adenomatous polyposis

✍ Scribed by Hideyuki Ishida; Takeo Iwama; Shigehisa Inokuma; Ikuya Takeuchi; Daijo Hashimoto; Michiko Miyaki


Publisher
Springer Japan
Year
2002
Tongue
English
Weight
336 KB
Volume
37
Category
Article
ISSN
0944-1174

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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T