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Analysis of K-ras, APC, and β-Catenin in Aberrant Crypt Foci in Sporadic Adenoma, Cancer, and Familial Adenomatous Polyposis

✍ Scribed by Tetsuji Takayama; Motoh Ohi; Tsuyoshi Hayashi; Koji Miyanishi; Atsushi Nobuoka; Takaharu Nakajima; Tsutomu Satoh; Rishu Takimoto; Junji Kato; Sumio Sakamaki; Yoshiro Niitsu


Book ID
119756338
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
729 KB
Volume
121
Category
Article
ISSN
0016-5085

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Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T