Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer—rarity of co-occurrence of mutations in APC, K-ras, and p53 genes

Mutation analysis of p53, K-ras, and BRA

Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression

✍ Daniele Calistri; Claudia Rengucci; Ian Seymour; Arturo Lattuneddu; Anna maria P 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 162 KB

## Abstract Gene mutations in __APC__, __K‐ras__, and __p53__ are thought to be essential events for colorectal cancer development. Recent data seem to indicate that __K‐ras__ and __p53__ mutations rarely co‐exist in the same tumor, indicating that these alterations do not represent a synergistic e