Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
β-Catenin and adenomatous polyposis coli (APC) mutations in adenomas from hereditary non-polyposis colorectal cancer patients
✍ Scribed by Yoshimitsu Akiyama; Hiromi Nagasaki; Kenji Osmar Yagi; Tadashi Nomizu; Yasuhito Yuasa
- Book ID
- 117466587
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 119 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0304-3835
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A decrease in the intracellular concentrations of the transcripts for some tumor suppressor genes has been found during murine lung tumorigenesis; for p15 INK4b and p16 INK4a , this was due to homozygous deletions. We report here a decrease in the mRNA levels of the mutated in colorectal cancer (Mcc
Inactivation of the adenomatous polyposis coli (APC) gene has been shown to initiate the majority of colorectal cancer (CRC), including a familial form called familial adenomatous polyposis (FAP). One consequence of the APC mutation is the activation of the -catenin (CTNNB1)/T-cell transcription fa