## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients
โ Scribed by I.S. Boughdady; A.R. Kinsella; N.Y. Haboubi; P.F. Schofield
- Book ID
- 113404088
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 985 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0960-7404
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๐ SIMILAR VOLUMES
Familial adenomatous polyposis (FAP) represents a human model of the adenomasarcinoma sequence. Colectomy substantially reduces the cancer risk. Restorative proctocolectomy maintains continence and abolishes the risk of rectal cancer, but there is a price to pay in terms of an increased morbidity ra
We have observed and defined morphometrically and histochemically groups of undifferentiated columnar cells within the surface epithelium in colorectal mucosa. They were present within both non-polypoid and polypoid mucosa in familial adenomatous polyposis, and within non-hereditary adenomatous poly