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K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma

✍ Scribed by N. Peter Zauber; Marlene Sabbath-Solitare; Stephen P. Marotta; D. Timothy Bishop

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 151 KB
Volume: 86
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19990701)86:1<31::aid-cncr6>3.0.co;2-o

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✦ Synopsis

BACKGROUND.

The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in situ carcinoma provides an opportunity to evaluate genetic changes within a single neoplasia whose separate areas are comprised of both the benign adenoma as well as the malignant carcinoma.

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