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Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung

✍ Scribed by Steven A. Ahrendt; P. Anthony Decker; Enas A. Alawi; Yong-ran Zhu; Montserrat Sanchez-Cespedes; Stephen C. Yang; George B. Haasler; André Kajdacsy-Balla; Michael J. Demeure; David Sidransky


Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
77 KB
Volume
92
Category
Article
ISSN
0008-543X

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## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit