K-ras mutation and loss of heterozygosit
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N. Peter Zauber; Marlene Sabbath-Solitare; Stephen P. Marotta; D. Timothy Bishop
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Article
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1999
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John Wiley and Sons
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English
⚖ 151 KB
👁 1 views
## BACKGROUND. The majority of colorectal carcinomas, if not all, arise from a benign adenoma. The DNA of the carcinomatous cells frequently has mutations in several genes. However, it is not exactly clear when during the neoplastic process each mutation develops. An adenoma with an area of in sit