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Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas

โœ Scribed by Hitoshi Kondo; Kokichi Sugano; Noriko Fukayama; Koichi Hosokawa; Hisanao Ohkura; Atsushi Ohtsu; Kiyoshi Mukai; Shigeaki Yoshida


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
118 KB
Volume
79
Category
Article
ISSN
0008-543X

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โœฆ Synopsis


The authors previously found specific mutations of


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Mutations in the N-, K-, and H-ras genes are key events in the process of carcinogenesis of many human cancers and may serve as important targets for therapeutic intervention. We developed a simple diagnostic method that in one step and within 5 hr determines the mutational status of any of the 3 ra