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Antiprotozoal activity of Betulinic acid derivatives

✍ Scribed by D.B. Domínguez-Carmona; F. Escalante-Erosa; K. García-Sosa; G. Ruiz-Pinell; D. Gutierrez-Yapu; M.J. Chan-Bacab; A. Giménez-Turba; L.M. Peña-Rodríguez

Book ID
113848589
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
150 KB
Volume
17
Category
Article
ISSN
0944-7113

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New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at