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Design, synthesis, and anti-tumor activity of novel betulinic acid derivatives

✍ Scribed by Liu, Jin-Hong; Tang, Jia; Zhu, Zi-Fei; Chen, Li


Book ID
126454907
Publisher
Taylor and Francis Group
Year
2013
Tongue
English
Weight
187 KB
Volume
16
Category
Article
ISSN
1028-6020

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New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at