Synthesis and cytotoxic activity of a-ring modified betulinic acid derivatives

✍ Scribed by Young-Jae You; Yong Kim; Nguyen-Hai Nam; Byung-Zun Ahn

• Book ID: 104364042
• Publisher: Elsevier Science
• Year: 2003
• Tongue: English
• Weight: 176 KB
• Volume: 13
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(03)00724-8

✦ Synopsis

New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.