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Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives

โœ Scribed by Yi Bi; Jinyi Xu; Xiaoming Wu; Wencai Ye; Shengtao Yuan; Luyong Zhang


Book ID
108074186
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
119 KB
Volume
17
Category
Article
ISSN
0960-894X

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New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at