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Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives

✍ Scribed by René Csuk; Stefan Schwarz; Bianka Siewert; Ralph Kluge; Dieter Ströhl


Book ID
113583114
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
792 KB
Volume
46
Category
Article
ISSN
0223-5234

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New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at