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Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid

✍ Scribed by Milan Urban; Martin Vlk; Petr Dzubak; Marian Hajduch; Jan Sarek


Book ID
113495801
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
349 KB
Volume
20
Category
Article
ISSN
0968-0896

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New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at