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Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD?

โœ Scribed by Tiina M. Asikainen; Carl W. White

Book ID
113923428
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
437 KB
Volume
203
Category
Article
ISSN
0041-008X

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Hypoxia-inducible factors (HIFs) are essential mediators of the cellular oxygen-signaling pathway. They are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (HIF-alpha) and a constitutive beta subunit (HIF-beta) that facilitate both oxygen delivery and adaptation t