Antidouble-stranded DNA isotypes in lupus erythematosus patients with prevalent cutaneous presentation

✍ Scribed by A. Parodi; M. Drosera; L. Barbieri; G. Babbini; A. Rebora

• Book ID: 104460258
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 46 KB
• Volume: 147
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2002.04939.x

✦ Synopsis

Background:

Antidouble-stranded dna antibodies (anti-dsdna ab), in particular of the igg isotype, are usually considered a marker of systemic lupus erythematosus and often correlate with the disease activity.

Objectives:

To determine igg, iga and igm anti-dsdna ab in a group of 330 patients with lupus erythematosus and prevalent cutaneous lesions.

Methods:

The titre of anti-dsdna ab was determined by enzyme-linked immunosorbent assay, and disease activity was assessed by means of the systemic lupus activity measure.

Results:

One hundred and six patients had anti-dsdna ab. thirty-nine patients had antibodies of all three isotypes of immunoglobulins, 17 had igg + igm, five igg + iga, and two iga + igm. forty-three patients had a single isotype of anti-dsdna ab. patients with systemic disease and higher disease activity had antibodies of all three isotypes of immunoglobulins or of igg isotype. remarkably, anti-dsdna ab of the iga isotype, alone or associated with igm, marked dermatological patients with low disease activity, but often with disquieting clinical and/or laboratory alterations.

Conclusions:

These results indicate a correlation between disease activity and both frequency and isotype of anti-dsdna ab.