Antibodies to single-stranded dna in patients with discoid lupus erythematosus

✍ Scribed by Kevin B. Kulick; Thomas T. Provost; Morris Reichlin

• Book ID: 102752281
• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 706 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780250606

✦ Synopsis

Sera from 31 patients with discoid lupus erythematosus were examined for the presence of antibodies to single-stranded and native DNA. None of these sera had antibodies to native DNA. When rabbit anti-human IgM was used, 6 of 28 patients had elevated binding, whereas only 1 of 29 patients had abnormal binding when antiIgG was used. The IgM nature of this response was confirmed when we demonstrated the binding activity in heavy fractions from gel filtration. We concluded that at least one-fifth of patients with discoid lupus erythematosus have IgM antibodies to single-stranded DNA.

Discoid lupus erythematosus (DLE) is a chronic, scarring dermatosis characterized by the development of erythematous plaques that eventually become atrophic and hyperpigmented. Systemic lupus erythematosus (SLE) is a multisystem disease associated with the development of various autoantibodies (1).

The relationship between DLE and SLE has been discussed for many years, at least since 1872,