Antibodies to Viral and Synthetic Double-Stranded RNA in Discoid Lupus Erythematosus
β Scribed by Robert A. Sylvester; Moises Attias; Norman Talal; Denny L. Tuffanelli
- Publisher
- John Wiley and Sons
- Year
- 1973
- Tongue
- English
- Weight
- 288 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0004-3591
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Numerous studies have characterized the physiological effects of synthetic, high-molecularweight, homopolymeric, double-stranded RNA (dsRNA), particularly polyriboinosinicΠΈpolyribocytidylic acid : Science 186:1172-1178], but limited information exists regarding the physiological effects of dsRNA of
We describe a patient with systemic lupus erythematosus who, after a disease flare, sequentially produced antibodies to specific Sm polypeptides (demonstrated by counterimmunoelectrophoresis, immunoblotting, and RNA immunoprecipitation) concomitantly with the disappearance of anti-double-stranded DN