𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Analysis of the serotonin transporter gene linked polymorphism (5-HTTLPR) in anorexia nervosa

✍ Scribed by Sundaramurthy, D.; Pieri, L.F.; Gape, H.; Markham, A.F.; Campbell, D.A.

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
8 KB
Volume
96
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(20000207)96:1<53::aid-ajmg11>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

Previous studies have demonstrated aberrant expression of serotonin in individuals with an eating disorder. Given this the serotonin transporter gene (5-HTT) is a strong candidate to contribute to the genetic component of the aetiology of eating disorders. To determine the role of this particular gene in the susceptibility to anorexia nervosa (AN) we have examined a tandemly repeated sequence close to the promotor region of the 5-HTT gene, which is represented by a long (L) and short (S) variant.

Previous studies have shown that the transcriptional activity of the 5-HTT gene differs significantly between these two alleles. A group of 138 Diagnostic and Statistical

Manual of Mental Disorders (DSM-IV) criteria AN patients and 90 controls were genotyped at the 5-HTT gene linked polymorphism (5-HTTLPR). Statistical analysis showed no significant difference in allele or genotype frequencies between the two groups. These data suggest that there is no association between 5-HTTLPR genotype and susceptibility to AN, in our population.

πŸ“œ SIMILAR VOLUMES

Serotonin transporter gene (5-HTT) polym
Serotonin transporter gene (5-HTT) polymorphisms and compulsive buying
✍ Devor, Eric J.; Magee, Harry J.; Dill-Devor, Rebecca M.; Gabel, Janelle; Black, πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 9 KB πŸ‘ 1 views

We examined a panel of 21 patients diagnosed with compulsive buying for two DNA sequence polymorphisms found in the gene that encodes the serotonin transport (5-HTT). One polymorphism, found in the promoter region of the 5-HTT gene, involves a 44-base pair (bp) deletion, and the other, found in the

Population studies of polymorphisms of t
Population studies of polymorphisms of the serotonin transporter protein gene
✍ Gelernter, J.; Cubells, J.F.; Kidd, J.R.; Pakstis, A.J.; Kidd, K.K. πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 41 KB πŸ‘ 2 views

The range of allele frequency variation in humans for any locus that may have functionally important genetic variation needs to be documented. Therefore, we tested two polymorphisms at the serotonin transporter protein locus (SLC6A4) in samples from seven specific populations from five continental r

No association between serotonin transpo
No association between serotonin transporter gene polymorphisms and personality traits
✍ Gustavsson, J. Petter; NοΏ½then, Markus M.; JοΏ½nsson, Erik G.; Neidt, Helge; Forslu πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 51 KB πŸ‘ 2 views

Human family and twin studies have established considerable heritable components in personality traits as assessed by selfreport questionnaires. Recently, an association between a functional polymorphism in the upstream regulatory region of the serotonin transporter gene and neuroticismrelated perso

Serotonin transporter (5-HTT) gene and b
Serotonin transporter (5-HTT) gene and bipolar affective disorder
✍ Esterling, Lisa E.; Yoshikawa, Takeo; Turner, Gordon; Badner, Judy A.; Bengel, D πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 15 KB πŸ‘ 2 views

Interactions with antidepressants, as well as other biochemical evidence, implicate the serotonin transporter 5-HTT in the etiology of affective disorders. However, genetic studies have produced conflicting results concerning an association of 5-HTT with bipolar disorder. We examined a variable numb

Analysis of GNAZ gene polymorphism in bi
Analysis of GNAZ gene polymorphism in bipolar affective disorder
✍ Saito, Takuya; Papolos, Demitri F.; Chernak, Danielle; Rapaport, Mark H.; Kelsoe πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 16 KB πŸ‘ 2 views

Evidence for a bipolar disorder (BPD) susceptibility locus on chromosome 22q11 has been provided in several studies. One candidate gene that maps to this region is the G-protein ␣ subunit gene G␣z (GNAZ). We have identified a common silent polymorphism in GNAZ exon 2 by single strand conformation po