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An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

โœ Scribed by Yi, Xiaoming; White, Dennis M.; Aisner, Dara L.; Baur, Joseph A.; Wright, Woodring E.; Shay, Jerry W.

Book ID
122154483
Publisher
Neoplasia Press
Year
2000
Tongue
English
Weight
312 KB
Volume
2
Category
Article
ISSN
1522-8002

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Hypermethylation of the human telomerase
Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome