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Telomerase activity and expression of human telomerase catalytic subunit gene in esophageal lesions

โœ Scribed by Tominaga, Tatsuro; Kashimura, Hiromasa; Suzuki, Kaori; Ohkawa, Jun; Itabashi, Masayuki; Watanabe, Teruo; Nakahara, Akira; Tanaka, Naomi

Book ID
122607590
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
175 KB
Volume
118
Category
Article
ISSN
0016-5085

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Hypermethylation of the human telomerase
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โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome