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Demethylation of the human telomerase catalytic subunit (hTERT) gene promoter reduced hTERT expression and telomerase activity and shortened telomeres

โœ Scribed by Isabelle Guilleret; Jean Benhattar


Book ID
117099934
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
310 KB
Volume
289
Category
Article
ISSN
0014-4827

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Hypermethylation of the human telomerase
โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome