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Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase

โœ Scribed by Masako Yago; Rieko Ohki; Shinji Hatakeyama; Toshiro Fujita; Fuyuki Ishikawa

Book ID
117104233
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
442 KB
Volume
520
Category
Article
ISSN
0014-5793

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Hypermethylation of the human telomerase
Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome