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Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT)

โœ Scribed by Joseph C Poole; Lucy G Andrews; Trygve O Tollefsbol

Book ID
117520341
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
847 KB
Volume
269
Category
Article
ISSN
0378-1119

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Hypermethylation of the human telomerase
Hypermethylation of the human telomerase catalytic subunit (hTERT) gene correlates with telomerase activity
โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome