DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome
โฆ LIBER โฆ
Regulation of the human catalytic subunit of telomerase (hTERT)
โ Scribed by Michael Daniel; Gregory W. Peek; Trygve O. Tollefsbol
- Book ID
- 116508748
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 661 KB
- Volume
- 498
- Category
- Article
- ISSN
- 0378-1119
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## BACKGROUND. Telomerase activation is thought to be essential for the stabilization of telomere length, through which immortalization and oncogenesis are achieved, but little is known about the regulation of telomerase in human gastric carcinoma cells. ## METHODS. A total of 27 primary gastri