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Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

โœ Scribed by S. Kharbanda; V. Kumar; S. Dhar; P. Pandey; C. Chen; P. Majumder; Z-M. Yuan; Y. Whang; W. Strauss; T.K. Pandita; D. Weaver; D. Kufe


Book ID
114317657
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
206 KB
Volume
10
Category
Article
ISSN
0960-9822

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Hypermethylation of the human telomerase
โœ Isabelle Guilleret; Pu Yan; Fabienne Grange; Richard Braunschweig; Fred T. Bosma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 443 KB

DNA methylation is an epigenetic process involved in embryonic development, differentiation and aging. It is 1 of the mechanisms resulting in gene silencing in carcinogenesis, especially in tumor suppressor genes (e.g., p16, Rb). Telomerase, the DNA polymerase adding TTAGGG repeats to the chromosome