Alterations of the p15, p16, and p18 genes in osteosarcoma
β Scribed by C.W. Miller; A. Aslo; M.J. Campbell; N. Kawamata; B.C. Lampkin; H.P. Koeffler
- Book ID
- 113253661
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 1000 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0165-4608
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## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.
We have examined the roles of 2 putative tumor-suppressor genes, the p16 and p15 inhibitor-of-cyclin-dependentkinase genes, in the most commonly occurring epithelial tumors of the human ovary. Expression of p16 mRNA, examined by RT-PCR, was significantly reduced in 15 of the 48 tumors. Aberrant expr