Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia
β Scribed by Machiko Kawamura; Hiroaki Ohnishi; Shu-Xia Guo; Xiao Ming Sheng; Masayoshi Minegishi; Ryoji Hanada; Keizo Horibe; Teruaki Hongo; Yasuhiko Kaneko; Fumio Bessho; Masayoshi Yanagisawa; Takao Sekiya; Yasuhide Hayashi
- Book ID
- 114119550
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 255 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0145-2126
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## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.
## Abstract Bβcell chronic lymphocytic leukemia (BβCLL) samples were screened for alterations in multiple tumor suppressor genes (__p53__ (17p13), __p__16 INK^4^ (9p21), and disrupted in Bβcell malignancy (__DBM__) (13q14)) by using polyβmerase chain reactionβbased assays. Eleven percent (11 of 96)