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Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia

✍ Scribed by Machiko Kawamura; Hiroaki Ohnishi; Shu-Xia Guo; Xiao Ming Sheng; Masayoshi Minegishi; Ryoji Hanada; Keizo Horibe; Teruaki Hongo; Yasuhiko Kaneko; Fumio Bessho; Masayoshi Yanagisawa; Takao Sekiya; Yasuhide Hayashi


Book ID
114119550
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
255 KB
Volume
23
Category
Article
ISSN
0145-2126

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## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.

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## Abstract B‐cell chronic lymphocytic leukemia (B‐CLL) samples were screened for alterations in multiple tumor suppressor genes (__p53__ (17p13), __p__16 INK^4^ (9p21), and disrupted in B‐cell malignancy (__DBM__) (13q14)) by using poly‐merase chain reaction‐based assays. Eleven percent (11 of 96)