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Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas

✍ Scribed by Toshihide Tsuzuki; Shigeru Tsunoda; Toshisuke Sakaki; Noboru Konishi; Yoshio Hiasa; Mitsutoshi Nakamura

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 637 KB
Volume: 78
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19960715)78:2<287::aid-cncr15>3.0.co;2-s

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✦ Synopsis

BACKGROUND.

Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.

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