We have examined the roles of 2 putative tumor-suppressor genes, the p16 and p15 inhibitor-of-cyclin-dependentkinase genes, in the most commonly occurring epithelial tumors of the human ovary. Expression of p16 mRNA, examined by RT-PCR, was significantly reduced in 15 of the 48 tumors. Aberrant expr
Alteration of p16 and p15 genes in human uterine tumours
β Scribed by Nakashima, R; Fujita, M; Enomoto, T; Haba, T; Yoshino, K; Wada, H; Kurachi, H; Sasaki, M; Wakasa, K; Inoue, M
- Book ID
- 110002196
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 346 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-0920
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## BACKGROUND. Alterations of the suppressor genes, such as the retinoblastoma (RB), p53, pl6(CDKN2), and p15 genes, have been reported in human gliomas. These genes have been suggested as the cell cycle regulatory genes at the G,-S checkpoint.
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## Background: It has been suggested that cyclin-dependent kinase inhibitors (cdkis), including p16 and p15, are tumor suppressor genes. alterations of cdkis have been found in most types of cancer. however, little is known about the status of p16 and p15 genes, including methylation of the promote