Alterations in the expression of Ia antigens in F1hybrid mice

✍ Scribed by Mauro S. Sandrin; Glen H. Tobias; Ian F. C. McKenzie; Gunter J. Hämmerling

• Publisher: Springer-Verlag
• Year: 1981
• Tongue: English
• Weight: 610 KB
• Volume: 14
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00350122

✦ Synopsis

The Ia.8 and 9 specificities detected either by conventional or monoclonal antisera (Ia.m3, 4) are present in strains bearing the b H-2 haplotype, but absent from those with the k haplotype. It would be expected that the (b x k)F1 hybrids would have approximately half the amount of these specificities found on the b parent, but the Ia.8 and 9 specificities are absent or reduced in this F 1 hybrid, though not on F 1 LPS blasts. Examination of appropriate H-2 congenic strains demonstrated that only the k haplotype confers the absence of these specificities on H-2 b -it was not observed with b, d, q, r or s haplotypes. In the k haplotype the gene(s) responsible for this effect is mapped to the I-A k subregion. The reason for this "low expression" effect is not clear but the observation has important implications for the relationship of Ia specificities and Ir genes and may serve to explain the "low responder" status of certain FI hybrids, e. g., to TNP-mouse serum albumin, as observed elsewhere.