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Altered antigen expression of microglia in the aged rodent CNS

✍ Scribed by V. H. Perry; M. K. Matyszak; S. Fearn

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
835 KB
Volume
7
Category
Article
ISSN
0894-1491

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✦ Synopsis

Microglia, the resident macrophages o f the central nervous system, are characterised by a highly specialized morphology and unusual antigenic phenotype. Microglia appear to he downregulated b.y their microenvironment when compared to other tissue macrophages. We have studied the microglia in brains of healthy, aged rats with a pancl of monoclonal antibodies. We have found that microglia in the brains of these aged rats express antigens that are downregulated or absent from microglia of juvenile rats. The stimuli which give rise to this upregulated phenotype are not known. Age related changes in the phenotype of microglia should be taken into account when considering the possible role of microglia in neuropathologcal conditions.

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