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Independent regulation of serologically distinct idiotypes in F1hybrid mice

✍ Scribed by Thomas F. Kresina; Mitchell J. Nelles; Alfred Nisonoff; Alan R. Brown

Publisher
Springer-Verlag
Year
1984
Tongue
English
Weight
692 KB
Volume
19
Category
Article
ISSN
0093-7711

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✦ Synopsis

We have investigated the regulation of expression of two distinct intrastrain cross-reactive idiotypes, CRI A and CRIc, characteristic of anti-pazophenylarsonate (anti-Ar) antibodies of the A/J and BALB/c strains, respectively, in (BALB/c x A/J)F1 (CAF1) mice. Such hybrid mice were found to synthesize antibodies with each idiotype when immunized against the Ar hapten group, although the expression of each was significantly reduced as compared with the parental strain. CAF 1 mice were pretreated with idiotypic-specific antibody reagents and subsequently hyperimmunized against the Ar hapten. Analysis of the idiotypes present in immune sera showed that suppression of either CRI did not concomitantly suppress the expression of the other. Alteration of the expression of one idiotype was not, however, without influence on the other; the expression of CRI c was markedly enhanced in mice suppressed for CRI A.

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