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Age and strain dependence of O6-methylguanine DNA methyltransferase activity in mice

✍ Scribed by Nakatsuru, Yoko; Aoki, Kazuko; Ishikawa, Takatoshi

Book ID
123479451
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
620 KB
Volume
219
Category
Article
ISSN
0921-8734

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Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove