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Specific Recognition of O 6 -Methylguanine in DNA by Active Site Mutants of Human O 6 -Methylguanine-DNA Methyltransferase †

✍ Scribed by Hazra, Tapas K.; Roy, Rabindra; Biswas, Tapan; Grabowski, David T.; Pegg, Anthony E.; Mitra, Sankar


Book ID
127232138
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
235 KB
Volume
36
Category
Article
ISSN
0006-2960

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Activity of 06-methylguanine-DNA methyltransferase (MGMT) is well related with drug resistance of tumor cells to chloroethylnitrosoureas (CENUs), because MGMT removes CENU-induced O6-alkyIguanines in DNA by accepting the alkyl group at a cysteine moiety. Inactivation of MGMT is a feasible way to ove