𝔖 Bobbio Scriptorium
✦   LIBER   ✦

O6-Methylguanine-DNA methyltransferase in human cells

✍ Scribed by Daniel B. Yarosh; Mary Rice; Rufus S. Day III; Robert S. Foote; Sankar Mitra

Book ID
116107994
Publisher
Elsevier Science
Year
1984
Weight
764 KB
Volume
131
Category
Article
ISSN
0167-8817

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Tamoxifen accelerates proteasomal degrad
Tamoxifen accelerates proteasomal degradation of O6-methylguanine DNA methyltransferase in human cancer cells
✍ Ching-Chuan Kuo; Jin-Fen Liu; Her-Shyong Shiah; Li-Chen Ma; Jang-Yang Chang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 412 KB

## Abstract Tamoxifen, a synthetic triphenyl‐ethylene compound, is a member of a class of anticancer drugs known as selective estrogen receptor modulators. It may block tumor growth by mimicking estrogen and binding to the estrogen receptors, preventing cancerous growth. Clinical studies have demon

Contribution of O6-methylguanine-DNA met
Contribution of O6-methylguanine-DNA methyltransferase to monofunctional alkylating-agent resistance in human brain tumor—derived cell lines
✍ Michael S. Bobola; A. Blank; Mitchel S. Berger; John R. Silber 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 997 KB

## Abstract The DNA repair protein __O__^6^‐methylguanine‐DNA methyltransferase (MGMT) has been implicated in resistance of human brain tumors to alkylating agents. We observed that 14 human medulloblastoma‐ and gliomaderived cell lines differ in sensitivity to the methylating agent __N__‐methyl‐__

Expression of human O6-methylguanine-DNA
Expression of human O6-methylguanine-DNA methyltransferase in chinese hamster ovary cells and restoration of cellular resistance to certain N-nitroso compounds
✍ Zining Wu; Chung-Leung Chan; Alan Eastman; Edward Bresnick 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

We have constructed a plasmid in which the expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA is driven by the Rous sarcoma virus promoter sequence. Transfection of this plasmid into Chinese hamster ovary (CHO) cells results in expression of MGMT and in cellular resistance to N-m