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Adenosine A1receptors using 8-dicyclopropylmethyl-1-[11C]methyl-3-propylxanthine PET in Alzheimer’s disease

✍ Scribed by Nobuyoshi Fukumitsu; Kenji Ishii; Yuichi Kimura; Keiichi Oda; Masaya Hashimoto; Masahiko Suzuki; Kiichi Ishiwata

Book ID
107614164
Publisher
Springer Japan
Year
2008
Tongue
English
Weight
361 KB
Volume
22
Category
Article
ISSN
0914-7187

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## Abstract Synthesis of [__O__‐methyl‐^11^C]‐4‐(1,3‐dimethoxy‐2‐propylamino)‐2,7‐dimethyl‐8‐(2,4‐dichlorophenyl)[1,5‐a]pyrazolo‐1,3,5‐triazine ([^11^C]DMP696), a highly selective CRF~1~ antagonist has been achieved. The total time required for the synthesis of [^11^C]DMP696 is 30 min from EOB usin