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Synthesis of [O-methyl-11C]-4-(1,3-dimethoxy-2-propylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)[1,5-a]pyrazolo-1,3,5-triazine ([11C]DMP696): a potential PET ligand for CRF1 receptors

✍ Scribed by J. S. Dileep Kumar; Vattoly J. Majo; Norman R. Simpson; Jaya Prabhakaran; Ronald L. Van Heertum; J. John Mann

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
96 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Synthesis of [O‐methyl‐^11^C]‐4‐(1,3‐dimethoxy‐2‐propylamino)‐2,7‐dimethyl‐8‐(2,4‐dichlorophenyl)[1,5‐a]pyrazolo‐1,3,5‐triazine ([^11^C]DMP696), a highly selective CRF~1~ antagonist has been achieved. The total time required for the synthesis of [^11^C]DMP696 is 30 min from EOB using [^11^C]methyl triflate in THF, with a 16% yield (EOS) and >99% chemical and radiochemical purities along with a specific activity of >2000 Ci/mmol (EOS). Copyright © 2004 John Wiley & Sons, Ltd.

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