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Abnormalities of theP16INK4A gene in thyroid cancer cell lines

✍ Scribed by M. Ivan; D. Wynford-Thomas; C.J. Jones

Book ID
117663528
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
328 KB
Volume
32
Category
Article
ISSN
0959-8049

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The p 16INK4 tumor-suppressor gene (also known as CDKNZ, CDK41 and MTSI) encodes a negative regulator of the cell cycle. This gene, located in 9pZ I, is mutated or homozygously deleted in a high percentage of tumor cell lines and specific types of primary tumors. We have examined the status of the p