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High frequency deletion of the tumour suppressor gene P16INK4a (MTS1) in human thyroid cancer cell lines

✍ Scribed by C.J Jones; J.J Shaw; F.S Wyllie; N Gaillard; M Schlumberger; D Wynford-Thomas

Book ID
116122719
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
640 KB
Volume
116
Category
Article
ISSN
0303-7207

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The p 16INK4 tumor-suppressor gene (also known as CDKNZ, CDK41 and MTSI) encodes a negative regulator of the cell cycle. This gene, located in 9pZ I, is mutated or homozygously deleted in a high percentage of tumor cell lines and specific types of primary tumors. We have examined the status of the p